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[ 292 ] In TME, tumor cells can manipulate the activity of immune cells, suppress the attack of immune cells on cancer cells, and evade immune surveillance by the body

186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria

Thioredoxin is a relatively small regulatory protein serving an important redox function

These data are intended solely for basic scientific investigation of biological mechanisms and do not imply any therapeutic, diagnostic, preventive, or clinical use in humans or animals

(2018) Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors, Oncol

Definitions of variables The primary outcome was doctor-diagnosed gout, and the secondary outcomes were mean serum uric acid levels and hyperuricemia