My body had lost the fight
Pediatrics 110 , 377385 (2002)
Several lines of evidence demonstrate memory deficits concurrent with copper deposition in the choroid plexus, astrocyte swelling (Alzheimer type II cells), astrogliosis and neuronal degeneration in the cerebral cortex, and augmented levels of copper and zinc in the hippocampus of chronically copper-intoxicated rats [337]
Mechanistically, at very low, non-toxic concentrations, the peptide stimulates collagen, glycosaminoglycans, and proteoglycans such as decorin, while modulating the matrix metalloproteinases involved in extracellular matrix remodeling during healing
In patients with severe hepatic or renal disease, effects of therapy should be followed with serial liver and/or renal function tests
Therefore, a deeper exploration of the relationship and regulatory effects between these processes can offer a solid foundation for disease treatment