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Modulating the GSH-GCL axis or targeting cysteine redox signaling represents a promising therapeutic avenue for IPF (Fig

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Symptoms of CTS usually begin gradually, rather than after an injury

Differences in 24-h urine composition between nephrolithiasis patients with and without diabetes mellitus

Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]

On one hand, gut dysbiosis facilitates ferroptosis by affecting iron metabolic pathways, like blocking the synthesis and release of hepatic hepcidin and expression of the iron transporter FPN1 to inhibit iron efflux and causing systemic and local iron overload in joints, thus leading to ferroptosis in OA chondrocytes