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Nat Rev Cancer

J Autoimmun (2011) 36(3-4):189200

10.1016/j.redox.2021.101976 Redox Biol

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)

A., Matherly, L