Amylin and Cagrilintide activate CGRP-like neurons in the AP that project to: Nucleus tractus solitarius (NTS) , autonomic center Parabrachial nucleus , integration of taste and satiety Hypothalamic pathways , energy balance The result: strong central appetite suppression and stabilization of satiety between meals
J Appl Physiol 2011;110(3):774-780
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Unlike oral supplements, nasal sprays bypass the digestive system, which is where the compound can be prone to breakdown this can also be said for injectables
This proposed connection to GILZ-mediated signalling could help explain DSIPs anti-inflammatory effects and its capacity to modulate immune function, though this remains a hypothesis under investigation
This purging phase typically lasts two to four weeks