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Martens A, Wistuba-Hamprecht K, Geukes Foppen M, Yuan J, Postow MA, Wong P, et al

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

For the duration of the study, both groups continued to receive their current standard of care treatment for PD [Parkinsons disease], investigators added

Allow any alcohol to dry completely before proceeding, as inserting a needle into wet alcohol can sting

Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity

The areas of interest are the effects on glycemia, body weight, and cardiovascular risk markers