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www.legislation.gov.uk

[90] These symptoms can include cravings for nicotine, anger, irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating

Moreover, the US Department of Health and Human Services pointed out that tobacco smokers undergo a substantial build-up of genetic mutations due to the complex chemical composition of tobacco smoke 61

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Smokers and smokeless tobacco users exhibited distinct oral microbiome profiles compared to healthy controls, with higher microbial diversity and significant compositional differences