228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable targetincreased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels
[DOI] [PubMed] [Google Scholar] 517
Hamida, R
Animals and housing Following laboratory animal welfare (3Rs: Replacement, Reduction, and Refinement) best practice [31], we acquired 13 adult female mice (C57BL/6 background) from another lab which were excess to experimental requirements, experimentally nave, and slated for euthanasia
As a result, the peptide concentration in the tumor site can be increased, the anti-cancer efficiency of the AMPs can be enhanced, and the toxic side effects on normal tissues can be reduced
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