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N = 6 rats/group

Regulation by AKT and 14-3-3 proteins

40 Hepcidin deficiency resulting from these mutations ultimately leads to excessive absorption of dietary iron

While more human research is needed, early results are very promising

Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)

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