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Neelakantan et al

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Two caveats are essential

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In addition, several clinical trials have shown their potential in treating various disorders, including cognitive and behavioral disorders, narcolepsy, and other significant neurological disorders, such as AD and PD, that have been reviewed extensively elsewhere [16]

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed