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Shutting-down the glucose-glycogen bypass pathway resulted in more glucose being driven into the glycolytic pathway to generate more ATP

This helps repair damaged skin cells and enhances the skin's ability to fight environmental aggressors such as pollution and UV radiation

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Furthermore, the paper explores how these regulatory mechanisms affect NRF2s roles in oxidative stress, inflammation, and cell death, identifying novel therapeutic targets and strategies

During ferroptosis, cells release the DAMP high-mobility group box 1 (HMGB1) by autophagy-dependent processes