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A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]

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DNM RECOMMENDS: Four Leaf Rover offers Guts & Glory, a selection of organs and glands from pasture-raised New Zealand cows

Bioorg Med Chem Lett 23:12571261 Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng J-H, Carulli E, Fang X (2016) Synthesis and biological evaluation of N-((1-(4-(sulfonyl) piperazin-1-yl) cycloalkyl) methyl) benzamide inhibitors of glycine transporter-1

Drouin-Ouellet J, Sawiak SJ, Cisbani G, Lagac M, Kuan W-L, Saint-Pierre M, et al

However, new models must be developed to elucidate the sophisticated viral mechanisms that converge with cell stress and genetic risk to definitively provide a link between enteroviruses and T1D initiation