doi: 10.1007/s40610-020-00140-1
Pintaudi, B., Di Vieste, G
The citric acid cycle involves three NAD+-dependent dehydrogenase reactions: isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and malate dehydrogenase, each generating NADH while releasing carbon dioxide and regenerating oxaloacetate for continued cycle operation
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*Reduction of Oxidative Stress: Helps neutralize free radicals, reducing cell damage and slowing the aging process
However, the efficacy of this strategy in the context of vascular aging remains to be elucidated, prompting our further investigation in this area