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HIF-1 activation not only promotes metabolic reprogramming in tumor cells (e.g., enhancing glycolysis) but also induces vascular endothelial growth factor (VEGF) expression, leading to new blood vessel formation that supplies additional oxygen and nutrients to tumor cells ( Figure 2 Studies have shown that a low-iron environment can induce epithelial-mesenchymal transition (EMT), enhancing tumor cells' migratory and invasive abilities and increasing their metastatic potential

Most authors reported a decrease in TPOAb and TgAb levels after using different doses of Se (selenomethionine) supplements with or without L-T4 (73, 74)

Recent updates on anticancer mechanisms of polyphenols

FOLIC ACID Folic acid participates in the synthesis of some amino acids, such as methionine / homocysteine and glutamic acid, contributes to normal hematopoiesis or to the normal process of blood cell formation

Atkinson, S

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