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In a clinical study, it was demonstrated that cigarette smoking induces pyloric incompetence and increases the duodenogastric reflux (39), which may be due to the reduction in basal pyloric pressure induced by smoking (40), leading to mucosal injury in the stomach

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Risks of vaping include: Nicotine exposure : E-cigarettes can deliver a large dose of nicotine, which can harm brain development in fetuses, children, and teens

There is growing data that suggests nicotine and its derivatives stimulate and support important mechanisms involved in the development of GI malignancies [68]

The crude model included only the exposure variable

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