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Cardiovasc Res 118(10):e69e71 Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, ODonnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA (2013) Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association

doi: 10.1016/j.ajps.2019.04.003

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The JAMA study explicitly modeled these indications and still found that once family factors were controlled via siblings, the association went away