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In type 2 diabetes mellitus, portal vein insulin levels are elevated to compensate for the insulin-resistant state of the body

Kushner A, West WP, Pillarisetty LS (2021) Virchow Triad

Further, despite the persistent notion that all diuretics might have diabetogenic properties, long-term studies in preclinical animal models are still missing and many questions remain unanswered regarding the mechanisms whereby these drugs may exert their metabolic effects under different chronic contexts

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