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Additional promoting mechanisms include Par-4-stimulated, NCOA4-mediated ferritinophagy (52) and autophagic degradation of GSH reductase, which reduces GSH synthesis and antioxidant capacity, further promoting ferroptosis (53)

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Furthermore, silencing or knocking down NSD2 leads to a significant reduction in the activation of multiple oncogenes ( ADAM2 , EGFR , Sox2 , Bcl-2 , SYK , and MET )

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The phospholipid is optionally salted or desalted, hydrogenated or partially hydrogenated, natural, synthetic, or semisynthetic