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a , Cryo-EM map of the GPIT complex with six additional transmembrane helices, viewed in parallel to the membrane plane

Certain medications, including acetaminophen and chemotherapy drugs, may interact with glutathione, so consult your doctor if you are on any medication.

However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

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Schonberg, D

Each assay was carried out with three replicates