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Their accumulation increases free radical production, stimulates the release of pro-inflammatory factors, and exacerbates inflammatory reactions

Individuals with the homozygous variant TT genotype in MTHFR appear to have reduced MTHFR enzyme activity and thus impaired folate metabolism and OCM

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"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis" (PDF)

Mukherjee A, Malik H, Saha AP, Dubey A, Singhal DK, Boateng S, Saugandhika S,Kumar S, De S, Guha SK, Malakar D

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