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[2] Reduces Inflammation: Oxidative stress triggers inflammation

doi: 10.1007/s00438-024-02135-4 40 OnalT.Ozgul-OnalM.ChefetzI

IGF-1 LR3 is used as a research tool for studying IGF-1 receptor (IGF-1R) signaling, PI3K/Akt/mTOR pathway activation, and insulin receptor cross-reactivity in vitro

We next further investigated whether the observed bell-shaped profile induced by high concentrations of dimeric macrocycles (3,000 nM) or HGF (30 nM) might be due to off-target inhibition of constitutively activated RTKs, which could potentially transactivate Met phosphorylation

Wu 2012)