Lung cancer management with silibinin: a historical and translational perspective
When the supply of cysteine is low, GSH synthesis is impaired and cells can become sensitive to oxidative stress or undergo ferroptosis-like damage
Grube M, Leiske MN, Schubert US, Nischang I
What is emerging is that diseases known to be underpinned by oxidative stress are proving to be more responsive to such amplification of cellular defences via Nrf2 activation than by administration of direct-acting antioxidant supplements [22, 94]
Thus, LPS treatment resulted in significant increases in permeability and glycocalyx loss, IFN alone had minimal effects, while the combination of both treatments led to the most substantial increases in permeability and glycocalyx loss [126]
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