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Chronic infection and inflammation can deplete endogenous antioxidants such as glutathione, catalase, and vitamins C and E, resulting in amplification for the oxidative stress and cellular damage, and this may have negative effect by causing damage to the alveolar-capillary membrane which causes increased permeability, pulmonary edema, decreased gas exchange, and prolonged oxidative stress causing inflammation, fibrosis, and long-term lung damage