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At the outdoor bar, patrons looked up from their baskets of stone crabs to gawk

The beneficial effects have been determined only by the pharmacologic properties, ignoring bioavailability and pharmacokinetics, by examining effects in concentrations that are often impossible to achieve in vivo (157)

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Some evidence obtained in rodent models suggests that agents or natural extracts with antioxidant properties, such as melatonin and oil onion may prevent the nicotine-induced myocardial injury by activating antioxidant defense and reducing oxidative stress (Helen et al., 1999

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