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Olszewska-Pazdrak B, Carney DH

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In particular, in insulin-resistant human muscle biopsies, hypoxia and AICAR-stimulated GLUT4 translocation ex vivo was impaired, even though these stimuli do not engage the classical insulin signalling pathway [45,46]

It is important to notice that the hydrolysis of SAH to Hcy and adenosine is the only reversible reaction in the cycle