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Because vitamin B 12 in supplements is not bound to protein, and because intrinsic factor (IF) is still available, the absorption of supplemental vitamin B 12 is not reduced as it is in pernicious anemia

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So when were saying biotin causes acne because it affects B5 levels, how much biotin do you need to be consuming for it to affect B5

These tests determine how long a drug remains effective under specified storage conditions