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doi: 10.1016/j.freeradbiomed.2011.06.010

The concern isn't BDNF elevation itself but the possibility of compensatory downregulation of endogenous BDNF production if exogenous signaling is chronically sustained

How Long Does It Take For Sermorelin To Work: Clinical Evidence and Personalized Timelines Sermorelin typically requires 36 months to demonstrate measurable effects on growth hormone secretion, though individual responses vary significantly based on age, baseline hormone levels, and genetic predispositions

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(PubMed) Pearce EN, Leung AM, Blount BC, et al