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Ginkgolide B, a major component of Ginkgo biloba , protects against ototoxicity caused by cisplatin in vitro and in vivo by decreasing ROS production through the reduction of NOX2 expression and the enhancement of activity via the Akt/Nrf-2/HO-1 pathway, mitochondrial apoptosis is inhibited (Ma et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] Lucarelli D

52 , W521W525 (2024)

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules) and antioxidants in the body