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10.1056/NEJMc0800582 84 MoradiM.HaghighatdoostF.FeiziA.LarijaniB.AzadbakhtL

These cells play fundamental roles, both in brain development by promoting the maturation of neurons and oligodendrocytes [52] and in the adult brain, by performing functions typical of macrophages such as phagocytosing various types of cellular debris and pathogens, but also regulating and maturing synapses through phagocytosis and the release of various factors, including cytokines, chemokines and extracellular vesicles [53,54]

Frequently Asked Questions If semaglutide has a 7-day half-life, why can't I take a larger dose less frequently