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A significant amount of research has indicated that individuals with anaemia frequently experience osteoporosis as well (125, 126), which may be related to iron overload-mediated ferroptosis caused by long-term blood transfusions in anaemia patients (127), and their fracture risk is associated with the frequency of blood transfusions (128)

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These astrocytes exhibit reduced glutamate reuptake and diminished production of neurotrophic factors, ultimately leading to motor neuron loss