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Because your brain chemistry has been fundamentally altered by the high-dose mucosal absorption, quitting abruptly will trigger intense physical withdrawal symptoms

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Participants in clinical trials are encouraged to completely switch from cigarettes to e-cigarettes to minimize dual use, which has been shown to be harmful and may make it harder to quit tobacco use, says Maya Vijayaraghavan, MD, a professor in the Department of Medicine at the University of California San Francisco (UCSF) School of Medicine and the director of the UCSF Smoking Cessation Leadership Center