Very few peptide drugs are available in oral formulations due to the challenges of gastrointestinal degradation and poor absorption
This pathway is central to the cellular stress response mechanism
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ATP7A is expressed in various tissues and organs, whereas ATP7B is predominantly expressed in the liver, suggesting that ATP7A, but not ATP7B, is primarily involved in the exporting of copper into the brain cell (Lutsenko et al., 2007)
In animal models, BPC-157 has been studied most extensively for tendon healing, GI mucosal repair, bone repair, and neuroprotection
