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Decision Guidance Choose cagrilintide + tirzepatide when you want the strongest single-agent base (tirzepatide is FDA-approved and outperforms semaglutide head-to-head) plus amylin layering

The Shoulder If someone is giving you a B12 injection in the shoulder, have them make a downward-facing v-shape with your thumb and forefinger over the deltoid (shoulder) muscle

This fundamental difference drives the efficacy gap

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