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This extended protocol adds intermediate dose steps (0.5mg, 3mg, 6mg) that do not appear in the standard clinical trial schedule

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Interestingly, the impact of pro-inflammatory cytokines on neurogenesis is not limited to proliferation, cell death, and neuronal differentiation, but may also impact the integration of newly generated neurons in the adult brain [105]

113 It was then fused to the constant region (Fc) of modified human immunoglobulin G4 (IgG4) via a -(Gly-Gly-Gly-Gly-Ser) 3-Ala- bridge and exhibits an average biological half-life of 90 h

Reactions to the B12 itself could also occur, but they are extremely rare