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In the second stage, these factors enter the maternal blood circulation and promote systemic inflammatory responses and endothelial dysfunction, resulting in a series of clinical manifestations

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An 8-week randomized double-blind trial compared GHK-Cu in a nano-lipid carrier against Matrixyl 3000 and found a 55.8% reduction in wrinkle volume versus control serum, along with a 32.8% reduction in wrinkle depth

Lindahl A, Isgaard J, Carlsson L, Isaksson OG