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While its not entirely clear whether reduced proteasome function directly causes these disorders or simply contributes to them, this type of impairment has been observed in several conditions, including Alzheimers Parkinsons, Huntingtons, Prion diseases, and ALS (also known as Lou Gehrigs disease)

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suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model

reported that under high hydrostatic pressure, downregulation of cystathionine lyase/hydrogen sulfide (CSE/H 2 S) induce ferroptosis thereby exacerbating VSMC dysfunction

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[DOI] [PubMed] [Google Scholar] 128.Tanaka A, Kawaguchi A, Tomiyama H, et al