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In the case of eWAT, an increase in endogenous fatty acids following adherence to a HFD activates two sensors within adipocytes, Toll-like receptor 4(TLR4) and inflammasomes, which causes an influx of neutrophils to enter the eWAT, leading to increased levels of chemokine and cytokine expression (132)

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Calcium sensitization is a mechanism that is largely independent of intracellular calcium levels and enables modulation of smooth muscle contraction by altering the sensitivity of myosin light chain (MLC) to calcium

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