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Deletion of the Rac1 protein triggers the development of epilepsy by inducing neuronal hyper-excitability and reducing of GABAerigic inhibitory current in the hippocampus through inhibition of autophagy (Vaghi et al

The AUC of LC and ALC were 0.801 and 0.898, respectively

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Animal studies indicate a beneficial effect of the flavonoid curcumin on TTR amyloidosis, where it significantly reduced ATTR aggregate deposition in the dorsal root ganglia [36]