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Next, microarray analysis was performed using samples in which the opacity was reduced by glutamate, and genes whose expression increased with galactose culture and decreased with the addition of glutamate were extracted

Regarding the apoptotic marker caspase-3, our study demonstrated that lung caspase-3 was upregulated by HIR and this was consistent with a previous study that revealed a similar finding in an acute renal injury model in rats 32

doi: 10.1096/fj.02-0752rev 40 Chiorcea-PaquimAM

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Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation