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The disruption caused by SHANK3 mutations impairs receptor binding in neurons and oligodendrocytes, leading to messaging problems and myelin deficits, which contribute to autism-related symptoms

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Neurology 2019;92(12):e1322e1330

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The combined application of Vit C and CoQ10 resulted in TOS levels nearly equivalent to those in the control group, demonstrating the synergistic potential of this treatment regimen