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Clinical Insight Social isolation is a potent, biologically mediated driver of negative affect and aggressionpartly via tachykinin 2 signalingwith preclinical evidence that NK3 receptor antagonism can normalize isolation-induced aggression, fear, and anxiety without sedation

Indeed, glutathione is recruited into the nucleus early in the cell cycle in both mammals and plants (Markovic et al., 2007

Concentrations of GSH and GSSG were calculated from the IS calibration by interpolating the constructed linear-regression curves, with the analyte to IS peak ratios measured from sample solutions

The fact that nesfatin-1 co-localizes with neuroendocrine hormones, such as GHRH or somatostatin, may support this possibility

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References (1) Flanagan JL, et al