In biological systems, it plays a role in wound healing, tissue remodeling, and cellular repair
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Half-life 24h, relevant for long-term in vivo protocols
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These sequences, named as CIRTs (Cytoplasmic Intron-sequence Retaining Transcripts), comprise only few introns and are limited to small fractions of introns within the gene (Buckley et al., KCNMA1 gene (Bell et al., GABRG3 ) (Buckley et al., GRIK1 gene) and type 1 NMDA receptor (encoded by GRIN1) (Buckley et al., CACNA1H ) (Zhong et al., In this order of ideas, it is tempting to speculate that CIRT in Gpx4-I gene may be part of the normal endogenous post-transcriptional regulation pathway
