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Thus, ER stress-induced CHAC1 expression depletes GSH, compromises GPX4 function, and promotes ferroptotic cell death ( 4.5.3 Possible role of methionine Prolonged methionine deprivation blocks CHAC1 protein synthesis by interfering with its translation, thereby inhibiting ferroptosis

Glutathione is considered the universal antioxidant: it is the most important one in the body

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Our analysis revealed that GSH levels were significantly higher in ER+ breast cancer cells compared to ER- breast cancer cells (Fig

Psychiatry 26 , 65506561 (2021)