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NCBI National Center for Biotechnology Information Search 3GRS: REFINED STRUCTURE OF GLUTATHIONE REDUCTASE AT 1.54 ANGSTROMS RESOLUTION PDB ID: 3GRS Download MMDB ID: 58319 PDB Deposition Date: 1988/2/5 Updated in MMDB: 2011/10 Experimental Method: x-ray diffraction Resolution: 1.54 Source Organism: Homo sapiens Similar Structures: VAST+ Download sequence data Biological Unit for 3GRS: dimeric

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Glutathione: This is a very powerful antioxidant which is principally used to brighten and enhance skin complexion

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This indicates the existence of a GGCT-mediated Gln metabolic shunt in tumor cells: Gln is prioritized for conversion to GSH, which scavenges ROS, alleviates oxidative stress, and ultimately promotes tumor cell proliferation

Acta 508 , 122129 (2020)