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To strengthen the evidence base, future research should adhere to rigorous methodological standards, including well-defined eligibility criteria, stratification of participants by tinnitus type and duration, standardized intervention protocols, use of validated outcome measures, adequate sample size calculation, and extended follow-up to evaluate sustained effects

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In the presence of GSH, as shown in Fig

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While cytosolic and blood GSH and Cys biochemical species all experience depletion, the model predicts that a single exposure to doxorubicin only results in a minimal perturbation of the antioxidant defence system

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Conceptually, aOoC whose cells derive from representative patient subgroups or from responder versus non-responder cohorts could be used to identify treatment response biomarkers

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