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What researchers do know is that these toxic chemicals and metals have all been found in e-cigarettes: Nicotine a highly addictive substance that negatively affects adolescent brain development Propylene glycol a common additive in food

The nicotine content depends on the tobacco blend, size, and how long you smoke it

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Over time, the brain adapts by: Reducing natural dopamine production Requiring higher doses of nicotine to feel the same effects Increasing cravings and irritability without nicotine The National Institute on Drug Abuse (NIDA) reports that nicotine produces addiction-related brain changes comparable to other highly addictive substances, helping explain why quitting can feel difficult even after relatively short-term use

Sometimes there are differences in the population groups or the timespans studied

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