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Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)

doi: 10.4049/jimmunol.165.3.1618

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For example, the cytoprotective action of H 2 S on cells under ischemia was abrogated upon depletion of SQR (Hine et al., 2015), implicating a role for the mitochondrial H 2 S oxidation pathway in cytoprotection