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The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans

For each mouse, baseline 2 H spectra were obtained followed by around 1 min intravenous infusion of [6,6]- 2 H 2 glucose (d66, Aladdin

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Missing data for the trial product estimand were handled through multiple imputation using the Markov Chain Monte Carlo method, assuming that non-adherent participants would have responded similarly to adherent participants within the same treatment arm