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Senolytic CAR T cells reverse senescence-associated pathologies

Ewert A, Leifheit-Nestler M, Hohenfellner K, Buscher A, Kemper MJ, Oh J, Billing H, Thumfart J, Stangl G, Baur AC, Foller M, Feger M, Weber LT, Acham-Roschitz B, Arbeiter K, Tonshoff B, Zivicnjak M, Haffner D (2020) Bone and mineral metabolism in children with nephropathic cystinosis compared with other CKD entities

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In the context of protein oxidation, the relationship between AGEs and the generation of AOPPs is noteworthy (Figure 2) ( AGEs are produced in a slow and controlled process, accumulating in the body, including the skin ( 3.2.3 Protein carbonylation In addition to AOPPs and AGEs, protein carbonylation (PC) serves as another marker of protein oxidation in patients with AD