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The pivotal role of FDX1 in this pathway is underscored by experimental evidence that genetic ablation of FDX1 confers significant protection against DOX-induced cardiotoxicity in mice, preserving the left ventricular ejection fraction [76]

Brandlistuen RE, Ystrom E, Nulman I, Koren G, Nordeng H

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doi: 10.1038/s41598-018-21570-z 111 ZhaoXZhuYHuJJiangLLiLJiaSet al

In line with our Compass results, B6 MZB showed increased 2-NBDG uptake compared to B6 FoB (Fig